Open AccessThe Role of Platelet Reactivity and Genotype Testing in the Prevention of Atherothrombotic Cardiovascular Events Remains Unproven
Author(s) -
Vamsi Krishna,
George Diamond,
Sanjay Kaul
Publication year - 2012
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.111.075242
Subject(s) - medicine , platelet , platelet aggregation , genotype , cardiology , genetics , biology , gene
lopidogrel is the second-leading drug sold worldwide,yet 13 years and millions of patients treated later, we arejust beginning to understand the complexity of its metabolismand antiplatelet effects. There is a high degree of clopidogrelresponse variability in terms of pharmacokinetic and pharma-codynamic effects related to genetic and nongenetic fac-tors.
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