Interleukin-1β Is Crucial for the Induction of Coronary Artery Inflammation in a Mouse Model of Kawasaki Disease | Zendy

Youngho Lee | Zendy; Danica J. Schulte | Zendy; Kenichi Shimada | Zendy; Shuang Chen | Zendy; Timothy R. Crother | Zendy; Norika Chiba | Zendy; Michael C. Fishbein | Zendy; Thomas J A Lehman | Zendy; Moshe Arditi | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Interleukin-1β Is Crucial for the Induction of Coronary Artery Inflammation in a Mouse Model of Kawasaki Disease

Author(s) -

Youngho Lee,

Danica J. Schulte,

Kenichi Shimada,

Shuang Chen,

Timothy R. Crother,

Norika Chiba,

Michael C. Fishbein,

Thomas J A Lehman,

Moshe Arditi

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.072769

Subject(s) - medicine , kawasaki disease , inflammation , coronary artery disease , cardiology , disease , artery

Kawasaki disease (KD) is the most common cause of acute vasculitis and acquired cardiac disease in US children. Untreated, children may develop coronary artery aneurysms, myocardial infarction, and sudden death as a result of the illness. Up to a third of KD patients fail to respond to intravenous immunoglobulin, the standard therapy, and alternative treatments are being investigated. Genetic studies have indicated a possible role for interleukin (IL)-1β in KD. We therefore explored the role of IL-1β in a murine model of KD.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research