A Randomized and Clinical Effectiveness Trial Comparing Two Pharmacogenetic Algorithms and Standard Care for Individualizing Warfarin Dosing (CoumaGen-II) | Zendy

Jeffrey L. Anderson | Zendy; Benjamin D. Horne | Zendy; Scott M. Stevens | Zendy; Scott C. Woller | Zendy; Kent M. Samuelson | Zendy; Justin W. Mansfield | Zendy; Michelle Robinson | Zendy; Stephanie Barton | Zendy; Kim Brunisholz | Zendy; Chrissa P. Mower | Zendy; John Huntinghouse | Zendy; Jeffrey Rollo | Zendy; Dustin Siler | Zendy; Tami L. Bair | Zendy; Stacey Knight | Zendy; Joseph B. Muhlestein | Zendy; John F. Carlquist | Zendy

Open Access

A Randomized and Clinical Effectiveness Trial Comparing Two Pharmacogenetic Algorithms and Standard Care for Individualizing Warfarin Dosing (CoumaGen-II)

Author(s) -

Jeffrey L. Anderson,

Benjamin D. Horne,

Scott M. Stevens,

Scott C. Woller,

Kent M. Samuelson,

Justin W. Mansfield,

Michelle Robinson,

Stephanie Barton,

Kim Brunisholz,

Chrissa P. Mower,

John Huntinghouse,

Jeffrey Rollo,

Dustin Siler,

Tami L. Bair,

Stacey Knight,

Joseph B. Muhlestein,

John F. Carlquist

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.070920

Subject(s) - medicine , dosing , vkorc1 , randomized controlled trial , warfarin , pharmacogenetics , adverse effect , therapeutic index , clinical trial , algorithm , cyp2c9 , pharmacology , drug , genotype , mathematics , atrial fibrillation , biochemistry , chemistry , cytochrome p450 , metabolism , gene

Warfarin is characterized by marked variations in individual dose requirements and a narrow therapeutic window. Pharmacogenetics (PG) could improve dosing efficiency and safety, but clinical trials evidence is meager.

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