Activity of the Estrogen-Metabolizing Enzyme Cytochrome P450 1B1 Influences the Development of Pulmonary Arterial Hypertension | Zendy

Kevin P. White | Zendy; Anne Katrine Johansen | Zendy; Margaret Nilsen | Zendy; Loredana Ciuclan | Zendy; Emma Wallace | Zendy; Leigh Paton | Zendy; A. Campbell | Zendy; Ian Morecroft | Zendy; Lynn Loughlin | Zendy; John McClure | Zendy; Matthew J. Thomas | Zendy; Kirsty M. Mair | Zendy; Margaret R. MacLean | Zendy

Open Access

Activity of the Estrogen-Metabolizing Enzyme Cytochrome P450 1B1 Influences the Development of Pulmonary Arterial Hypertension

Author(s) -

Kevin P. White,

Anne Katrine Johansen,

Margaret Nilsen,

Loredana Ciuclan,

Emma Wallace,

Leigh Paton,

A. Campbell,

Ian Morecroft,

Lynn Loughlin,

John McClure,

Matthew J. Thomas,

Kirsty M. Mair,

Margaret R. MacLean

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.062927

Subject(s) - cyp1b1 , pulmonary artery , right ventricular hypertrophy , estrogen , endocrinology , medicine , metabolite , pulmonary hypertension , cytochrome p450 , estrogen receptor , hypoxia (environmental) , pharmacology , chemistry , metabolism , cancer , breast cancer , organic chemistry , oxygen

Pulmonary arterial hypertension (PAH) is a hyperproliferative vascular disorder observed predominantly in women. Estrogen is a potent mitogen in human pulmonary artery smooth muscle cells and contributes to PAH in vivo; however, the mechanisms attributed to this causation remain obscure. Curiously, heightened expression of the estrogen-metabolizing enzyme cytochrome P450 1B1 (CYP1B1) is reported in idiopathic PAH and murine models of PAH.

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