Ventricular Assist Device Implantation Corrects Myocardial Lipotoxicity, Reverses Insulin Resistance, and Normalizes Cardiac Metabolism in Patients With Advanced Heart Failure | Zendy

Aalap Chokshi | Zendy; Konstantinos Drosatos | Zendy; Faisal H. Cheema | Zendy; Ruiping Ji | Zendy; Tuba Khawaja | Zendy; Shuiqing Yu | Zendy; Tomoko S. Kato | Zendy; Raffay Khan | Zendy; Hiroo Takayama | Zendy; Ralph Knöll | Zendy; Hendrik Milting | Zendy; Christine S. Chung | Zendy; Ulrich P. Jorde | Zendy; Yoshifumi Naka | Zendy; Donna Mancini | Zendy; Ira J. Goldberg | Zendy; P. Christian Schulze | Zendy

Open Access

Ventricular Assist Device Implantation Corrects Myocardial Lipotoxicity, Reverses Insulin Resistance, and Normalizes Cardiac Metabolism in Patients With Advanced Heart Failure

Author(s) -

Aalap Chokshi,

Konstantinos Drosatos,

Faisal H. Cheema,

Ruiping Ji,

Tuba Khawaja,

Shuiqing Yu,

Tomoko S. Kato,

Raffay Khan,

Hiroo Takayama,

Ralph Knöll,

Hendrik Milting,

Christine S. Chung,

Ulrich P. Jorde,

Yoshifumi Naka,

Donna Mancini,

Ira J. Goldberg,

P. Christian Schulze

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.060889

Subject(s) - insulin resistance , medicine , lipotoxicity , heart failure , endocrinology , protein kinase b , insulin , insulin receptor , phosphorylation , biology , biochemistry

Heart failure is associated with impaired myocardial metabolism with a shift from fatty acids to glucose use for ATP generation. We hypothesized that cardiac accumulation of toxic lipid intermediates inhibits insulin signaling in advanced heart failure and that mechanical unloading of the failing myocardium corrects impaired cardiac metabolism.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research