Pathogenic Cycle Between the Endogenous Nitric Oxide Synthase Inhibitor Asymmetrical Dimethylarginine and the Leukocyte-Derived Hemoprotein Myeloperoxidase | Zendy

Eike-Christin von Leitner | Zendy; Anna Klinke | Zendy; Dorothee Atzler | Zendy; Jessica L. Slocum | Zendy; Natalie Lund | Zendy; Jan T. Kielstein | Zendy; Renke Maas | Zendy; Robin Schmidt-Haupt | Zendy; Michaela Pekarová | Zendy; Olaf Hellwinkel | Zendy; Dimitrios Tsikas | Zendy; Louis G. D’Alecy | Zendy; Denise Lau | Zendy; Stephan Willems | Zendy; Lukáš Kubala | Zendy; Heimo Ehmke | Zendy; Thomas Meinertz | Zendy; Stefan Blankenberg | Zendy; Edzard Schwedhelm | Zendy; Crystal A. Gadegbeku | Zendy; Rainer H. Böger | Zendy; Stephan Baldus | Zendy; Karsten Sydow | Zendy

Open Access

Pathogenic Cycle Between the Endogenous Nitric Oxide Synthase Inhibitor Asymmetrical Dimethylarginine and the Leukocyte-Derived Hemoprotein Myeloperoxidase

Author(s) -

Eike-Christin von Leitner,

Anna Klinke,

Dorothee Atzler,

Jessica L. Slocum,

Natalie Lund,

Jan T. Kielstein,

Renke Maas,

Robin Schmidt-Haupt,

Michaela Pekarová,

Olaf Hellwinkel,

Dimitrios Tsikas,

Louis G. D’Alecy,

Denise Lau,

Stephan Willems,

Lukáš Kubala,

Heimo Ehmke,

Thomas Meinertz,

Stefan Blankenberg,

Edzard Schwedhelm,

Crystal A. Gadegbeku,

Rainer H. Böger,

Stephan Baldus,

Karsten Sydow

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.060541

Subject(s) - myeloperoxidase , nitric oxide , asymmetric dimethylarginine , nitric oxide synthase , chemistry , nadph oxidase , in vivo , biochemistry , lipopolysaccharide , pharmacology , medicine , endocrinology , inflammation , arginine , oxidative stress , biology , microbiology and biotechnology , amino acid

The nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) and the leukocyte-derived hemoprotein myeloperoxidase (MPO) are associated with cardiovascular diseases. Activation of monocytes and polymorphonuclear neutrophils (PMNs) with concomitant release of MPO is regulated in a nitric oxide-dependent fashion. The aim of the study was to investigate a potential 2-way interaction between ADMA and MPO.

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