Identification of a Monocyte-Predisposed Hierarchy of Hematopoietic Progenitor Cells in the Adventitia of Postnatal Murine Aorta | Zendy

Peter J. Psaltis | Zendy; Adriana Harbuzariu | Zendy; Sinny Delacroix | Zendy; Tyra A. Witt | Zendy; Eric Holroyd | Zendy; Daniel B. Spoon | Zendy; Scott J. Hoffman | Zendy; Shuchong Pan | Zendy; Laurel S. Kleppe | Zendy; Cheryl S. Mueske | Zendy; Rajiv Gulati | Zendy; Gurpreet S. Sandhu | Zendy; Robert D. Simari | Zendy

Open Access

Identification of a Monocyte-Predisposed Hierarchy of Hematopoietic Progenitor Cells in the Adventitia of Postnatal Murine Aorta

Author(s) -

Peter J. Psaltis,

Adriana Harbuzariu,

Sinny Delacroix,

Tyra A. Witt,

Eric Holroyd,

Daniel B. Spoon,

Scott J. Hoffman,

Shuchong Pan,

Laurel S. Kleppe,

Cheryl S. Mueske,

Rajiv Gulati,

Gurpreet S. Sandhu,

Robert D. Simari

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.059360

Subject(s) - stem cell , progenitor cell , bone marrow , hemangioblast , adventitia , haematopoiesis , endothelial stem cell , biology , immunology , hematopoietic stem cell , microbiology and biotechnology , adult stem cell , pathology , medicine , in vitro , biochemistry

Hematopoiesis originates from the dorsal aorta during embryogenesis. Although adult blood vessels harbor progenitor populations for endothelial and smooth muscle cells, it is not known if they contain hematopoietic progenitor or stem cells. Here, we hypothesized that the arterial wall is a source of hematopoietic progenitor and stem cells in postnatal life.

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