Open AccessMice With Cardiac Overexpression of Peroxisome Proliferator–Activated Receptor γ Have Impaired Repolarization and Spontaneous Fatal Ventricular Arrhythmias
Author(s) -
John Morrow,
Alexander N. Katchman,
Ni-Huiping Son,
Chad M. Trent,
Raffay Khan,
Takayuki Shiomi,
Haiyan Huang,
Vaibhav Amin,
Joshua Lader,
Carolina Vásquez,
Gregory E. Morley,
Jeanine D’Armiento,
Shunichi Homma,
Ira J. Goldberg,
Steven O. Marx
Publication year - 2011
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.111.056309
Subject(s) - medicine , endocrinology , qt interval , ventricular fibrillation , peroxisome proliferator activated receptor , cardiology , repolarization , ventricular tachycardia , cardiac function curve , genetically modified mouse , sudden cardiac death , qrs complex , sudden death , diabetes mellitus , heart failure , transgene , receptor , biology , electrophysiology , biochemistry , gene
Diabetes mellitus and obesity, which confer an increased risk of sudden cardiac death, are associated with cardiomyocyte lipid accumulation and altered cardiac electric properties, manifested by prolongation of the QRS duration and QT interval. It is difficult to distinguish the contribution of cardiomyocyte lipid accumulation from the contribution of global metabolic defects to the increased incidence of sudden death and electric abnormalities.
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