Vascular Klotho Deficiency Potentiates the Development of Human Artery Calcification and Mediates Resistance to Fibroblast Growth Factor 23 | Zendy

Kenneth Lim | Zendy; Tzongshi Lu | Zendy; Guerman Molostvov | Zendy; Christina Lee | Zendy; F.T. Lam | Zendy; Daniel Zehnder | Zendy; LiLi Hsiao | Zendy

Open Access

Vascular Klotho Deficiency Potentiates the Development of Human Artery Calcification and Mediates Resistance to Fibroblast Growth Factor 23

Author(s) -

Kenneth Lim,

Tzongshi Lu,

Guerman Molostvov,

Christina Lee,

F.T. Lam,

Daniel Zehnder,

LiLi Hsiao

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.053405

Subject(s) - medicine , klotho , fibroblast growth factor 23 , fibroblast growth factor , calcification , endocrinology , calcium , kidney , parathyroid hormone , receptor

Klotho is known to function as a cofactor for the phosphatonin, fibroblast growth factor (FGF)-23 at the kidney. FGF-23 levels rise in chronic kidney disease (CKD) despite progression of accelerated vascular calcification. There are currently conflicting data on whether FGF-23 may exhibit direct vasculoprotective effects in CKD.

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