The Development of Myocardial Fibrosis in Transgenic Mice With Targeted Overexpression of Tumor Necrosis Factor Requires Mast Cell–Fibroblast Interactions | Zendy

Weili Zhang | Zendy; Amanda L. Chancey | Zendy; HueiPing Tzeng | Zendy; Zhenqing Zhou | Zendy; Kory J. Lavine | Zendy; Feng Gao | Zendy; Natarajan Sivasubramanian | Zendy; Philip M. Barger | Zendy; Douglas L. Mann | Zendy

Open Access

The Development of Myocardial Fibrosis in Transgenic Mice With Targeted Overexpression of Tumor Necrosis Factor Requires Mast Cell–Fibroblast Interactions

Author(s) -

Weili Zhang,

Amanda L. Chancey,

HueiPing Tzeng,

Zhenqing Zhou,

Kory J. Lavine,

Feng Gao,

Natarajan Sivasubramanian,

Philip M. Barger,

Douglas L. Mann

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.052399

Subject(s) - mast cell , tumor necrosis factor alpha , myocardial fibrosis , medicine , fibrosis , fibroblast , endocrinology , endomyocardial fibrosis , cardiac fibrosis , biology , cell culture , immunology , genetics

Transgenic mice with cardiac-restricted overexpression of tumor necrosis factor (MHCsTNF mice) develop progressive myocardial fibrosis, diastolic dysfunction, and adverse cardiac remodeling. Insofar as tumor necrosis factor (TNF) does not directly stimulate fibroblast collagen synthesis, we asked whether TNF-induced fibrosis was mediated indirectly through interactions between mast cells and cardiac fibroblasts.

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