Glycogen Synthase Kinase-3α Limits Ischemic Injury, Cardiac Rupture, Post–Myocardial Infarction Remodeling and Death | Zendy

Hind Lal | Zendy; Jibin Zhou | Zendy; Firdos Ahmad | Zendy; Raihana Zaka | Zendy; Ronald J. Vagnozzi | Zendy; Morgan DeCaul | Zendy; James R. Woodgett | Zendy; Erhe Gao | Zendy; Thomas Force | Zendy

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Glycogen Synthase Kinase-3α Limits Ischemic Injury, Cardiac Rupture, Post–Myocardial Infarction Remodeling and Death

Author(s) -

Hind Lal,

Jibin Zhou,

Firdos Ahmad,

Raihana Zaka,

Ronald J. Vagnozzi,

Morgan DeCaul,

James R. Woodgett,

Erhe Gao,

Thomas Force

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.050666

Subject(s) - medicine , cardiology , myocardial infarction , ventricular remodeling , glycogen , gsk 3 , ischemic injury , glycogen synthase , ischemia , kinase , microbiology and biotechnology , biology

The molecular pathways that regulate the extent of ischemic injury and post-myocardial infarction (MI) remodeling are not well understood. We recently demonstrated that glycogen synthase kinase-3α (GSK-3α) is critical to the heart's response to pressure overload. However, the role, if any, of GSK-3α in regulating ischemic injury and its consequences is not known.

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