Placental Growth Factor Regulates Cardiac Inflammation Through the Tissue Inhibitor of Metalloproteinases-3/Tumor Necrosis Factor-α–Converting Enzyme Axis | Zendy

Daniela Carnevale | Zendy; Giuseppe Cifelli | Zendy; Giada Mascio | Zendy; Michele Madonna | Zendy; Mauro Sbroggió | Zendy; Cinzia Perrino | Zendy; Maria Grazia Persico | Zendy; Giacomo Frati | Zendy; Giuseppe Lembo | Zendy

Open Access

Placental Growth Factor Regulates Cardiac Inflammation Through the Tissue Inhibitor of Metalloproteinases-3/Tumor Necrosis Factor-α–Converting Enzyme Axis

Author(s) -

Daniela Carnevale,

Giuseppe Cifelli,

Giada Mascio,

Michele Madonna,

Mauro Sbroggió,

Cinzia Perrino,

Maria Grazia Persico,

Giacomo Frati,

Giuseppe Lembo

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.050500

Subject(s) - pressure overload , tumor necrosis factor alpha , medicine , endocrinology , angiogenesis , placental growth factor , inflammation , vascular endothelial growth factor , growth factor , matrix metalloproteinase , cancer research , heart failure , receptor , cardiac hypertrophy , vegf receptors

Heart failure is one of the leading causes of mortality and is primarily the final stage of several overload cardiomyopathies, preceded by an early adaptive hypertrophic response and characterized by coordinated cardiomyocyte growth, angiogenesis, and inflammation. Therefore, growth factors and cytokines have to be critically regulated during cardiac response to transverse aortic constriction. Interestingly, the dual properties of placental growth factor as an angiogenic factor and cytokine make it a candidate to participate in cardiac remodeling in response to hemodynamic overload.

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