Multipotent Vasculogenic Pericytes From Human Pluripotent Stem Cells Promote Recovery of Murine Ischemic Limb | Zendy

Ayelet Dar | Zendy; Hagit Domev | Zendy; Oren Ben-Yosef | Zendy; Maty Tzukerman | Zendy; Naama ZeeviLevin | Zendy; Atara Novak | Zendy; Igal Germanguz | Zendy; Michal Amit | Zendy; Joseph ItskovitzEldor | Zendy

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Multipotent Vasculogenic Pericytes From Human Pluripotent Stem Cells Promote Recovery of Murine Ischemic Limb

Author(s) -

Ayelet Dar,

Hagit Domev,

Oren Ben-Yosef,

Maty Tzukerman,

Naama ZeeviLevin,

Atara Novak,

Igal Germanguz,

Michal Amit,

Joseph ItskovitzEldor

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.048264

Subject(s) - induced pluripotent stem cell , pericyte , stem cell , vasculogenesis , microbiology and biotechnology , embryonic stem cell , regenerative medicine , cd146 , angiogenesis , medicine , mesenchymal stem cell , endothelial stem cell , multipotent stem cell , pathology , biology , cancer research , progenitor cell , cd34 , biochemistry , gene , in vitro

Pericytes represent a unique subtype of microvessel-residing perivascular cells with diverse angiogenic functions and multilineage developmental features of mesenchymal stem cells. Although various protocols for derivation of endothelial and/or smooth muscle cells from human pluripotent stem cells (hPSC, either embryonic or induced) have been described, the emergence of pericytes in the course of hPSC maturation has not yet been elucidated.

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