Exercise Training Attenuates MuRF-1 Expression in the Skeletal Muscle of Patients With Chronic Heart Failure Independent of Age | Zendy

Stephan Gielen | Zendy; Marcus Sandri | Zendy; Irina Kozarez | Zendy; Jürgen Kratzsch | Zendy; Daniel Teupser | Zendy; Joachim Thiery | Zendy; Sandra Erbs | Zendy; Norman Mangner | Zendy; Karsten Lenk | Zendy; Rainer Hambrecht | Zendy; Gerhard Schüler | Zendy; Volker Adams | Zendy

Open Access

Exercise Training Attenuates MuRF-1 Expression in the Skeletal Muscle of Patients With Chronic Heart Failure Independent of Age

Author(s) -

Stephan Gielen,

Marcus Sandri,

Irina Kozarez,

Jürgen Kratzsch,

Daniel Teupser,

Joachim Thiery,

Sandra Erbs,

Norman Mangner,

Karsten Lenk,

Rainer Hambrecht,

Gerhard Schüler,

Volker Adams

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.047381

Subject(s) - medicine , wasting , heart failure , anabolism , muscle atrophy , exercise intolerance , vastus lateralis muscle , skeletal muscle , endocrinology , cardiology

Muscle wasting occurs in both chronic heart failure (CHF) and normal aging and contributes to exercise intolerance and increased morbidity/mortality. However, the molecular mechanisms of muscle atrophy in CHF and their interaction with aging are still largely unknown. We therefore measured the activation of the ubiquitin-proteasome system and the lysosomal pathway of intracellular proteolysis in muscle biopsies of CHF patients and healthy controls in two age strata and assessed the age-dependent effects of a 4-week endurance training program on the catabolic-anabolic balance.

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