Notch Activation of Jagged1 Contributes to the Assembly of the Arterial Wall
Author(s) -
Lauren J. Manderfield,
Frances A. High,
Kurt A. Engleka,
Feiyan Liu,
Li Li,
Stacey Rentschler,
Jonathan A. Epstein
Publication year - 2011
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.111.047159
Subject(s) - notch signaling pathway , neural crest , microbiology and biotechnology , vascular smooth muscle , anatomy , jag1 , biology , signal transduction , endocrinology , embryo , smooth muscle
Notch signaling in vascular smooth muscle precursors is required for smooth muscle differentiation. Jagged1 expression on endothelium activates Notch in vascular smooth muscle precursors including those of neural crest origin to initiate the formation of a smooth muscle layer in a maturing blood vessel.
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