Matrix Metalloproteinase-10 Effectively Reduces Infarct Size in Experimental Stroke by Enhancing Fibrinolysis via a Thrombin-Activatable Fibrinolysis Inhibitor–Mediated Mechanism | Zendy

Josune Orbe | Zendy; Jaione Barrenetxe | Zendy; José Antonio Rodríguez | Zendy; Denis Vivien | Zendy; Cyrille Orset | Zendy; William C. Parks | Zendy; Timothy P. Birkland | Zendy; Rosario Serrano | Zendy; Ana Purroy | Zendy; Sara Martínez de Lizarrondo | Zendy; Eduardo AnglésCano | Zendy; José A. Páramo | Zendy

Open Access

Matrix Metalloproteinase-10 Effectively Reduces Infarct Size in Experimental Stroke by Enhancing Fibrinolysis via a Thrombin-Activatable Fibrinolysis Inhibitor–Mediated Mechanism

Author(s) -

Josune Orbe,

Jaione Barrenetxe,

José Antonio Rodríguez,

Denis Vivien,

Cyrille Orset,

William C. Parks,

Timothy P. Birkland,

Rosario Serrano,

Ana Purroy,

Sara Martínez de Lizarrondo,

Eduardo AnglésCano,

José A. Páramo

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.047100

Subject(s) - fibrinolysis , plasmin , medicine , fibrin , thrombin , tissue plasminogen activator , matrix metalloproteinase , plasminogen activator , pharmacology , plasminogen activator inhibitor 1 , in vivo , immunology , chemistry , biochemistry , platelet , biology , enzyme , microbiology and biotechnology

The fibrinolytic and matrix metalloproteinase (MMP) systems cooperate in thrombus dissolution and extracellular matrix proteolysis. The plasminogen/plasmin system activates MMPs, and some MMPs have been involved in the dissolution of fibrin by targeting fibrin(ogen) directly or by collaborating with plasmin. MMP-10 has been implicated in inflammatory/thrombotic processes and vascular integrity, but whether MMP-10 could have a profibrinolytic effect and represent a promising thrombolytic agent is unknown.

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