Auto-Antigenic Protein-DNA Complexes Stimulate Plasmacytoid Dendritic Cells to Promote Atherosclerosis | Zendy

Yvonne Döring | Zendy; Helga D. Manthey | Zendy; Maik Drechsler | Zendy; Dirk Lievens | Zendy; Remco T. A. Megens | Zendy; Oliver Soehnlein | Zendy; Martin Busch | Zendy; Marco Manca | Zendy; Rory R. Koenen | Zendy; Jaroslav Pelisek | Zendy; Mat J.A.P. Daemen | Zendy; Esther Lutgens | Zendy; Martin Zenke | Zendy; Christoph J. Binder | Zendy; Christian Weber | Zendy; Alma Zernecke | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Auto-Antigenic Protein-DNA Complexes Stimulate Plasmacytoid Dendritic Cells to Promote Atherosclerosis

Author(s) -

Yvonne Döring,

Helga D. Manthey,

Maik Drechsler,

Dirk Lievens,

Remco T. A. Megens,

Oliver Soehnlein,

Martin Busch,

Marco Manca,

Rory R. Koenen,

Jaroslav Pelisek,

Mat J.A.P. Daemen,

Esther Lutgens,

Martin Zenke,

Christoph J. Binder,

Christian Weber,

Alma Zernecke

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.046755

Subject(s) - medicine , antigen , dna , immunology , microbiology and biotechnology , biochemistry , biology

Inflammation has been closely linked to auto-immunogenic processes in atherosclerosis. Plasmacytoid dendritic cells (pDCs) are specialized to produce type-I interferons in response to pathogenic single-stranded nucleic acids, but can also sense self-DNA released from dying cells or in neutrophil extracellular traps complexed to the antimicrobial peptide Cramp/LL37 in autoimmune disease. However, the exact role of pDCs in atherosclerosis remains elusive.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research