Human Embryonic and Induced Pluripotent Stem Cell–Derived Cardiomyocytes Exhibit Beat Rate Variability and Power-Law Behavior | Zendy

Yael Mandel | Zendy; Amir Weissman | Zendy; Revital Schick | Zendy; Lili Barad | Zendy; Atara Novak | Zendy; Gideon Meiry | Zendy; Stanislav Goldberg | Zendy; Avraham Lorber | Zendy; Michael R. Rosen | Zendy; Joseph ItskovitzEldor | Zendy; Ofer Binah | Zendy

Open Access

Human Embryonic and Induced Pluripotent Stem Cell–Derived Cardiomyocytes Exhibit Beat Rate Variability and Power-Law Behavior

Author(s) -

Yael Mandel,

Amir Weissman,

Revital Schick,

Lili Barad,

Atara Novak,

Gideon Meiry,

Stanislav Goldberg,

Avraham Lorber,

Michael R. Rosen,

Joseph ItskovitzEldor,

Ofer Binah

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.045146

Subject(s) - sinoatrial node , induced pluripotent stem cell , beat (acoustics) , embryonic stem cell , medicine , cardiology , heart rate , neuroscience , biology , physics , blood pressure , acoustics , gene , biochemistry

The sinoatrial node is the main impulse-generating tissue in the heart. Atrioventricular conduction block and arrhythmias caused by sinoatrial node dysfunction are clinically important and generally treated with electronic pacemakers. Although an excellent solution, electronic pacemakers incorporate limitations that have stimulated research on biological pacing. To assess the suitability of potential biological pacemakers, we tested the hypothesis that the spontaneous electric activity of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) and induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) exhibit beat rate variability and power-law behavior comparable to those of human sinoatrial node.

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