Migraine Mutations Increase Stroke Vulnerability by Facilitating Ischemic Depolarizations | Zendy

Katharina EikermannHaerter | Zendy; Jeong Hyun Lee | Zendy; Izumi Yuzawa | Zendy; Christina Liu | Zendy; Zhipeng Zhou | Zendy; Hwa Kyoung Shin | Zendy; Yi Zheng | Zendy; Tao Qin | Zendy; Tobias Kurth | Zendy; Christian Waeber | Zendy; Michel D. Ferrari | Zendy; Arn M. J. M. van den Maagdenberg | Zendy; Michael A. Moskowitz | Zendy; Cenk Ayata | Zendy

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Migraine Mutations Increase Stroke Vulnerability by Facilitating Ischemic Depolarizations

Author(s) -

Katharina EikermannHaerter,

Jeong Hyun Lee,

Izumi Yuzawa,

Christina Liu,

Zhipeng Zhou,

Hwa Kyoung Shin,

Yi Zheng,

Tao Qin,

Tobias Kurth,

Christian Waeber,

Michel D. Ferrari,

Arn M. J. M. van den Maagdenberg,

Michael A. Moskowitz,

Cenk Ayata

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.045096

Subject(s) - medicine , cortical spreading depression , familial hemiplegic migraine , migraine , migraine with aura , stroke (engine) , cardiology , glutamate receptor , ischemia , aura , infarction , neuroscience , anesthesia , receptor , myocardial infarction , mechanical engineering , engineering , biology

Migraine is an independent risk factor for stroke. Mechanisms underlying this association are unclear. Familial hemiplegic migraine (FHM), a migraine subtype that also carries an increased stroke risk, is a useful model for common migraine phenotypes because of shared aura and headache features, trigger factors, and underlying glutamatergic mechanisms.

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