Cardiac G-Protein–Coupled Receptor Kinase 2 Ablation Induces a Novel Ca 2+ Handling Phenotype Resistant to Adverse Alterations and Remodeling After Myocardial Infarction | Zendy

Philip Raake | Zendy; Xiaoying Zhang | Zendy; Leif Erik Vinge | Zendy; Henriette Brinks | Zendy; Erhe Gao | Zendy; Naser Jaleel | Zendy; Yingxin Li | Zendy; MingXin Tang | Zendy; Patrick Most | Zendy; Gerald W. Dorn | Zendy; Steven R. Houser | Zendy; Hugo A. Katus | Zendy; Xiongwen Chen | Zendy; Walter J. Koch | Zendy

Open Access

Cardiac G-Protein–Coupled Receptor Kinase 2 Ablation Induces a Novel Ca ²⁺ Handling Phenotype Resistant to Adverse Alterations and Remodeling After Myocardial Infarction

Author(s) -

Philip Raake,

Xiaoying Zhang,

Leif Erik Vinge,

Henriette Brinks,

Erhe Gao,

Naser Jaleel,

Yingxin Li,

MingXin Tang,

Patrick Most,

Gerald W. Dorn,

Steven R. Houser,

Hugo A. Katus,

Xiongwen Chen,

Walter J. Koch

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.044255

Subject(s) - medicine , cardiology , myocardial infarction , phenotype , ventricular remodeling , ablation , gene , biochemistry , chemistry

G-protein-coupled receptor kinase 2 (GRK2) is a primary regulator of β-adrenergic signaling in the heart. G-protein-coupled receptor kinase 2 ablation impedes heart failure development, but elucidation of the cellular mechanisms has not been achieved, and such elucidation is the aim of this study.

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