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G-protein-coupled receptor kinase 2 (GRK2) is a primary regulator of β-adrenergic signaling in the heart. G-protein-coupled receptor kinase 2 ablation impedes heart failure development, but elucidation of the cellular mechanisms has not been achieved, and such elucidation is the aim of this study.

circulation

Cardiac G-Protein–Coupled Receptor Kinase 2 Ablation Induces a Novel Ca <sup>2+</sup> Handling Phenotype Resistant to Adverse Alterations and Remodeling After Myocardial Infarction

Cardiac G-Protein–Coupled Receptor Kinase 2 Ablation Induces a Novel Ca 2+ Handling Phenotype Resistant to Adverse Alterations and Remodeling After Myocardial Infarction

Cardiac G-Protein–Coupled Receptor Kinase 2 Ablation Induces a Novel Ca ²⁺ Handling Phenotype Resistant to Adverse Alterations and Remodeling After Myocardial Infarction