Safety and Efficacy of Allogeneic Cell Therapy in Infarcted Rats Transplanted With Mismatched Cardiosphere-Derived Cells | Zendy

Konstantinos Malliaras | Zendy; TaoSheng Li | Zendy; Daniel Luthringer | Zendy; John Terrovitis | Zendy; Ke Cheng | Zendy; Tarun Chakravarty | Zendy; Giselle Galang | Zendy; Yiqiang Zhang | Zendy; Florian Schoenhoff | Zendy; Jennifer E. Van Eyk | Zendy; Linda Marbán | Zendy; Eduardo Marbán | Zendy

Open Access

Safety and Efficacy of Allogeneic Cell Therapy in Infarcted Rats Transplanted With Mismatched Cardiosphere-Derived Cells

Author(s) -

Konstantinos Malliaras,

TaoSheng Li,

Daniel Luthringer,

John Terrovitis,

Ke Cheng,

Tarun Chakravarty,

Giselle Galang,

Yiqiang Zhang,

Florian Schoenhoff,

Jennifer E. Van Eyk,

Linda Marbán,

Eduardo Marbán

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.042598

Subject(s) - medicine , cell therapy , transplantation , immunology , immunogenicity , immunosuppression , angiogenesis , stem cell , cytokine , immune system , in vivo , cancer research , microbiology and biotechnology , biology

Cardiosphere-derived cells (CDCs) are an attractive cell type for tissue regeneration, and autologous CDCs are being tested clinically. However, autologous therapy necessitates patient-specific tissue harvesting and cell processing, with delays to therapy and possible variations in cell potency. The use of allogeneic CDCs, if safe and effective, would obviate such limitations. We compared syngeneic and allogeneic CDC transplantation in rats from immunologically-mismatched inbred strains.

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