Reduction in Mortality in Subjects With Homozygous Familial Hypercholesterolemia Associated With Advances in Lipid-Lowering Therapy | Zendy

Frederick J. Raal | Zendy; Gillian J. Pilcher | Zendy; Vanessa R. Panz | Zendy; Hendrick E. van Deventer | Zendy; Brigitte C. Brice | Zendy; Dirk Blom | Zendy; A. David Marais | Zendy

Open Access

Reduction in Mortality in Subjects With Homozygous Familial Hypercholesterolemia Associated With Advances in Lipid-Lowering Therapy

Author(s) -

Frederick J. Raal,

Gillian J. Pilcher,

Vanessa R. Panz,

Hendrick E. van Deventer,

Brigitte C. Brice,

Dirk Blom,

A. David Marais

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.042523

Subject(s) - medicine , familial hypercholesterolemia , hazard ratio , proportional hazards model , confidence interval , statin , adverse effect , cholesterol , gastroenterology , cardiology , endocrinology

Homozygous familial hypercholesterolemia is an inherited disorder caused by mutations in both low-density lipoprotein receptor alleles, which results in extremely elevated plasma low-density lipoprotein cholesterol concentrations and very early morbidity and mortality due to cardiovascular disease.

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