Impaired Autophagosome Clearance Contributes to Cardiomyocyte Death in Ischemia/Reperfusion Injury | Zendy

Xiucui Ma | Zendy; Haiyan Liu | Zendy; Sarah R. Foyil | Zendy; Rebecca J. Godar | Zendy; Carla J. Weinheimer | Zendy; Joseph A. Hill | Zendy; Abhinav Diwan | Zendy

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Impaired Autophagosome Clearance Contributes to Cardiomyocyte Death in Ischemia/Reperfusion Injury

Author(s) -

Xiucui Ma,

Haiyan Liu,

Sarah R. Foyil,

Rebecca J. Godar,

Carla J. Weinheimer,

Joseph A. Hill,

Abhinav Diwan

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.041814

Subject(s) - autophagosome , autophagy , programmed cell death , microbiology and biotechnology , lysosome , medicine , ischemia , reperfusion injury , downregulation and upregulation , biology , apoptosis , biochemistry , gene , enzyme

In myocardial ischemia, induction of autophagy via the AMP-induced protein kinase pathway is protective, whereas reperfusion stimulates autophagy with BECLIN-1 upregulation and is implicated in causing cell death. We examined flux through the macroautophagy pathway as a determinant of the discrepant outcomes in cardiomyocyte cell death in this setting.

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