Downregulation of TMEM16A Calcium-Activated Chloride Channel Contributes to Cerebrovascular Remodeling During Hypertension by Promoting Basilar Smooth Muscle Cell Proliferation | Zendy

Mi Wang | Zendy; Hui Yang | Zendy; Lingyun Zheng | Zendy; Zheng Zhang | Zendy; YongBo Tang | Zendy; GuanLei Wang | Zendy; YanHua Du | Zendy; Xiaofei Lv | Zendy; Jie Liu | Zendy; JiaGuo Zhou | Zendy; Guan Yong-yuan | Zendy

Open Access

Downregulation of TMEM16A Calcium-Activated Chloride Channel Contributes to Cerebrovascular Remodeling During Hypertension by Promoting Basilar Smooth Muscle Cell Proliferation

Author(s) -

Mi Wang,

Hui Yang,

Lingyun Zheng,

Zheng Zhang,

YongBo Tang,

GuanLei Wang,

YanHua Du,

Xiaofei Lv,

Jie Liu,

JiaGuo Zhou,

Guan Yong-yuan

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.041806

Subject(s) - downregulation and upregulation , medicine , calcium , smooth muscle , cell growth , cardiology , endocrinology , microbiology and biotechnology , biochemistry , biology , gene

The Ca(2+)-activated chloride channel (CaCC) plays an important role in a variety of physiological functions. In vascular smooth muscle cells, CaCC is involved in the regulation of agonist-stimulated contraction and myogenic tone. The physiological functions of CaCC in blood vessels are not fully revealed because of the lack of specific channel blockers and the uncertainty concerning its molecular identity.

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