Open AccessWnt Signaling Mediates Pathological Vascular Growth in Proliferative Retinopathy
Author(s) -
Jing Chen,
Andreas Stahl,
Nathan M. Krah,
Molly R. Seaward,
Roberta J. Dennison,
Przemysław Sapieha,
Jing Hua,
Colman J. Hatton,
Aimee M. Juan,
Christopher M. Aderman,
Keirnan Willett,
Karen I. Guerin,
Akiko Mammoto,
Matthew Campbell,
Lois E.H. Smith
Publication year - 2011
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.111.040337
Subject(s) - wnt signaling pathway , lrp5 , neovascularization , retinal , retinopathy , angiogenesis , medicine , cancer research , frizzled , pathology , signal transduction , microbiology and biotechnology , biology , endocrinology , ophthalmology , diabetes mellitus
Ischemic proliferative retinopathy, characterized by pathological retinal neovascularization, is a major cause of blindness in working-age adults and children. Defining the molecular pathways distinguishing pathological neovascularization from normal vessels is critical to controlling these blinding diseases with targeted therapy. Because mutations in Wnt signaling cause defective retinal vasculature in humans with some characteristics of the pathological vessels in retinopathy, we investigated the potential role of Wnt signaling in pathological retinal vascular growth in proliferative retinopathy.
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