Distinct Epigenomic Features in End-Stage Failing Human Hearts | Zendy

Mehregan Movassagh | Zendy; MunKit Choy | Zendy; David A. Knowles | Zendy; Lina Cordeddu | Zendy; Syed Haider | Zendy; Thomas A. Down | Zendy; Lee Siggens | Zendy; Ana Vujić | Zendy; Ilenia Simeoni | Zendy; Chris Penkett | Zendy; Martin Goddard | Zendy; Píetro Lió | Zendy; Martin R. Bennett | Zendy; Roger Foo | Zendy

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Distinct Epigenomic Features in End-Stage Failing Human Hearts

Author(s) -

Mehregan Movassagh,

MunKit Choy,

David A. Knowles,

Lina Cordeddu,

Syed Haider,

Thomas A. Down,

Lee Siggens,

Ana Vujić,

Ilenia Simeoni,

Chris Penkett,

Martin Goddard,

Píetro Lió,

Martin R. Bennett,

Roger Foo

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.040071

Subject(s) - epigenome , epigenomics , dna methylation , biology , genetics , epigenetics , cpg site , human genome , histone , gene , genome , gene expression

The epigenome refers to marks on the genome, including DNA methylation and histone modifications, that regulate the expression of underlying genes. A consistent profile of gene expression changes in end-stage cardiomyopathy led us to hypothesize that distinct global patterns of the epigenome may also exist.

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