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Proximal Cerebral Arteries Develop Myogenic Responsiveness in Heart Failure via Tumor Necrosis Factor-α–Dependent Activation of Sphingosine-1-Phosphate Signaling
Author(s) -
Jing Yang,
M. Hossein Noyan-Ashraf,
Anja Meißner,
Julia VoigtlaenderBolz,
Jeffrey T. Kroetsch,
Warren D. Foltz,
David A. Jaffray,
Amita Kapoor,
Abdul Momen,
Scott P. Heximer,
Hangjun Zhang,
Matthijs van Eede,
R. Mark Henkelman,
Stephen G. Matthews,
Darcy Lidington,
Mansoor Husain,
Steffen-Sebastian Bolz
Publication year - 2012
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.111.039644
Subject(s) - medicine , heart failure , cardiology , cerebral blood flow , tumor necrosis factor alpha , sphingosine , myocardial infarction , endocrinology , anesthesia , receptor
Heart failure is associated with neurological deficits, including cognitive dysfunction. However, the molecular mechanisms underlying reduced cerebral blood flow in the early stages of heart failure, particularly when blood pressure is minimally affected, are not known.

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