Reduced Degradation of the Chemokine MCP-3 by Matrix Metalloproteinase-2 Exacerbates Myocardial Inflammation in Experimental Viral Cardiomyopathy | Zendy

Dirk Westermann | Zendy; Kostantinos Savvatis | Zendy; Diana Lindner | Zendy; Christin Zietsch | Zendy; Peter Moritz Becher | Zendy; Elke Hammer | Zendy; Markus M. Heimesaat | Zendy; Stefan Bereswill | Zendy; Uwe Völker | Zendy; Felicitas Escher | Zendy; Alexander Riad | Zendy; Johanna Plendl | Zendy; Karin Klingel | Zendy; Wolfgang Poller | Zendy; HeinzPeter Schultheiß | Zendy; Carsten Tschöpe | Zendy

Open Access

Reduced Degradation of the Chemokine MCP-3 by Matrix Metalloproteinase-2 Exacerbates Myocardial Inflammation in Experimental Viral Cardiomyopathy

Author(s) -

Dirk Westermann,

Kostantinos Savvatis,

Diana Lindner,

Christin Zietsch,

Peter Moritz Becher,

Elke Hammer,

Markus M. Heimesaat,

Stefan Bereswill,

Uwe Völker,

Felicitas Escher,

Alexander Riad,

Johanna Plendl,

Karin Klingel,

Wolfgang Poller,

HeinzPeter Schultheiß,

Carsten Tschöpe

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.035964

Subject(s) - medicine , inflammation , matrix metalloproteinase , cardiomyopathy , chemokine , metalloproteinase , cardiology , immunology , heart failure

Myocarditis is an important cause for cardiac failure, especially in younger patients, followed by the development of cardiac dysfunction and death. The present study investigated whether gene deletion of matrix metalloproteinase-2 influences cardiac inflammation and function in murine coxsackievirus B3 (CVB3)-induced myocarditis.

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