Targeted Regional Injection of Biocomposite Microspheres Alters Post–Myocardial Infarction Remodeling and Matrix Proteolytic Pathways | Zendy

Jennifer A. Dixon | Zendy; Robert C. Gorman | Zendy; Robert E. Stroud | Zendy; Rupak Mukherjee | Zendy; Evan Meyer | Zendy; Nathaniel L. Baker | Zendy; Masato Morita | Zendy; Hirotsugu Hamamoto | Zendy; Liam P. Ryan | Zendy; Joseph H. Gorman | Zendy; Francis G. Spinale | Zendy

Open Access

Targeted Regional Injection of Biocomposite Microspheres Alters Post–Myocardial Infarction Remodeling and Matrix Proteolytic Pathways

Author(s) -

Jennifer A. Dixon,

Robert C. Gorman,

Robert E. Stroud,

Rupak Mukherjee,

Evan Meyer,

Nathaniel L. Baker,

Masato Morita,

Hirotsugu Hamamoto,

Liam P. Ryan,

Joseph H. Gorman,

Francis G. Spinale

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.035774

Subject(s) - medicine , myocardial infarction , matrix metalloproteinase , saline , ventricular remodeling , microsphere , cardiology , endocrinology , chemical engineering , engineering

Although localized delivery of biocomposite materials, such as calcium hydroxyapatite (CHAM), have been demonstrated to potentially attenuate adverse left ventricular (LV) remodeling after myocardial infarction (MI), the underlying biological mechanisms for this effect remain unclear. This study tested the hypothesis that targeted CHAM injections would alter proteolytic pathways (matrix metalloproteinases [MMPs] and tissue inhibitors of MMPs [TIMPs]) and would be associated with parameters of post-MI LV remodeling.

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