Immune Activation Resulting From NKG2D/Ligand Interaction Promotes Atherosclerosis | Zendy

Mingcan Xia | Zendy; Nadia Guerra | Zendy; Galina K. Sukhova | Zendy; Kangkang Yang | Zendy; Carla K. Miller | Zendy; GuoPing Shi | Zendy; David H. Raulet | Zendy; Na Xiong | Zendy

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Immune Activation Resulting From NKG2D/Ligand Interaction Promotes Atherosclerosis

Author(s) -

Mingcan Xia,

Nadia Guerra,

Galina K. Sukhova,

Kangkang Yang,

Carla K. Miller,

GuoPing Shi,

David H. Raulet,

Na Xiong

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.034850

Subject(s) - medicine , immune system , nkg2d , ligand (biochemistry) , inflammation , immunology , microbiology and biotechnology , receptor , cytotoxicity , biochemistry , in vitro , biology , chemistry

The interplay between the immune system and abnormal metabolic conditions sustains and propagates a vicious feedback cycle of chronic inflammation and metabolic dysfunction that is critical for atherosclerotic progression. It is well established that abnormal metabolic conditions, such as dyslipidemia and hyperglycemia, cause various cellular stress responses that induce tissue inflammation and immune cell activation, which in turn exacerbate the metabolic dysfunction. However, molecular events linking these processes are not well understood.

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