Low-Density Lipoprotein Receptor–Related Protein 1 Prevents Early Atherosclerosis by Limiting Lesional Apoptosis and Inflammatory Ly-6C high Monocytosis | Zendy

Patricia G. Yancey | Zendy; YuQiang Ding | Zendy; Daping Fan | Zendy; John Blakemore | Zendy; Youmin Zhang | Zendy; Lei Ding | Zendy; Jiabao Zhang | Zendy; MacRae F. Linton | Zendy; Sergio Fazio | Zendy

Open Access

Low-Density Lipoprotein Receptor–Related Protein 1 Prevents Early Atherosclerosis by Limiting Lesional Apoptosis and Inflammatory Ly-6C ^high Monocytosis

Author(s) -

Patricia G. Yancey,

YuQiang Ding,

Daping Fan,

John Blakemore,

Youmin Zhang,

Lei Ding,

Jiabao Zhang,

MacRae F. Linton,

Sergio Fazio

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.032268

Subject(s) - lrp1 , apolipoprotein e , ldl receptor , lipoprotein , medicine , endocrinology , apoptosis , biology , cancer research , cholesterol , biochemistry , disease

We previously demonstrated that macrophage low-density lipoprotein receptor (LDLR)-related protein 1 (LRP1) deficiency increases atherosclerosis despite antiatherogenic changes including decreased uptake of remnants and increased secretion of apolipoprotein E (apoE). Thus, our objective was to determine whether the atheroprotective effects of LRP1 require interaction with apoE, one of its ligands with multiple beneficial effects.

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