Downregulation of Kv7.4 Channel Activity in Primary and Secondary Hypertension | Zendy

Thomas A. Jepps | Zendy; Preet S. Chadha | Zendy; Alison Davis | Zendy; Maksym I. Harhun | Zendy; Gillian Cockerill | Zendy; SørenPeter Olesen | Zendy; Rie Schultz Hansen | Zendy; Iain A. Greenwood | Zendy

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Downregulation of Kv7.4 Channel Activity in Primary and Secondary Hypertension

Author(s) -

Thomas A. Jepps,

Preet S. Chadha,

Alison Davis,

Maksym I. Harhun,

Gillian Cockerill,

SørenPeter Olesen,

Rie Schultz Hansen,

Iain A. Greenwood

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.032136

Subject(s) - medicine , downregulation and upregulation , primary (astronomy) , cardiology , biochemistry , gene , chemistry , physics , astronomy

Voltage-gated potassium (K(+)) channels encoded by KCNQ genes (Kv7 channels) have been identified in various rodent and human blood vessels as key regulators of vascular tone; however, nothing is known about the functional impact of these channels in vascular disease. We ascertained the effect of 3 structurally different activators of Kv7.2 through Kv7.5 channels (BMS-204352, S-1, and retigabine) on blood vessels from normotensive and hypertensive animals.

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