Critical Role for Stromal Interaction Molecule 1 in Cardiac Hypertrophy | Zendy

JeanSébastien Hulot | Zendy; Jérémy Fauconnier | Zendy; Deepak Ramanujam | Zendy; Antoine H. Chaanine | Zendy; F. Cohen Aubart | Zendy; Yassine Sassi | Zendy; Sabine Merkle | Zendy; Olivier Cazorla | Zendy; Aude Ouillé | Zendy; Morgan Dupuis | Zendy; Lahouaria Hadri | Zendy; Dongtak Jeong | Zendy; Silke Mühlstedt | Zendy; Joachim P. Schmitt | Zendy; Attila Braun | Zendy; Ludovic Bénard | Zendy; Youakim Saliba | Zendy; Bernhard Laggerbauer | Zendy; Bernhard Nieswandt | Zendy; Alain Lacampagne | Zendy; Roger J. Hajjar | Zendy; AnneMarie Lompré | Zendy; Stefan Engelhardt | Zendy

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Critical Role for Stromal Interaction Molecule 1 in Cardiac Hypertrophy

Author(s) -

JeanSébastien Hulot,

Jérémy Fauconnier,

Deepak Ramanujam,

Antoine H. Chaanine,

F. Cohen Aubart,

Yassine Sassi,

Sabine Merkle,

Olivier Cazorla,

Aude Ouillé,

Morgan Dupuis,

Lahouaria Hadri,

Dongtak Jeong,

Silke Mühlstedt,

Joachim P. Schmitt,

Attila Braun,

Ludovic Bénard,

Youakim Saliba,

Bernhard Laggerbauer,

Bernhard Nieswandt,

Alain Lacampagne,

Roger J. Hajjar,

AnneMarie Lompré,

Stefan Engelhardt

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.031229

Subject(s) - stim1 , muscle hypertrophy , medicine , in vivo , myocyte , microbiology and biotechnology , biology , endocrinology , chemistry , calcium

Cardiomyocytes use Ca2+ not only in excitation-contraction coupling but also as a signaling molecule promoting, for example, cardiac hypertrophy. It is largely unclear how Ca2+ triggers signaling in cardiomyocytes in the presence of the rapid and large Ca2+ fluctuations that occur during excitation-contraction coupling. A potential route is store-operated Ca2+ entry, a drug-inducible mechanism for Ca2+ signaling that requires stromal interaction molecule 1 (STIM1). Store-operated Ca2+ entry can also be induced in cardiomyocytes, which prompted us to study STIM1-dependent Ca2+ entry with respect to cardiac hypertrophy in vitro and in vivo.

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