NADPH Oxidase 4 Promotes Endothelial Angiogenesis Through Endothelial Nitric Oxide Synthase Activation | Zendy

Siobhan M. Craige | Zendy; Kai Chen | Zendy; Yongmei Pei | Zendy; Chunying Li | Zendy; Xiaoyun Huang | Zendy; C.-R. Chen | Zendy; Rei Shibata | Zendy; Kaori Sato | Zendy; Kenneth Walsh | Zendy; John F. Keaney | Zendy

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NADPH Oxidase 4 Promotes Endothelial Angiogenesis Through Endothelial Nitric Oxide Synthase Activation

Author(s) -

Siobhan M. Craige,

Kai Chen,

Yongmei Pei,

Chunying Li,

Xiaoyun Huang,

C.-R. Chen,

Rei Shibata,

Kaori Sato,

Kenneth Walsh,

John F. Keaney

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.030775

Subject(s) - nox4 , enos , nadph oxidase , angiogenesis , nitric oxide synthase type iii , nitric oxide synthase , nitric oxide , endothelial stem cell , reactive oxygen species , endothelium , hypoxia (environmental) , microbiology and biotechnology , biology , medicine , endocrinology , chemistry , biochemistry , oxygen , in vitro , organic chemistry

BACKGROUND- Reactive oxygen species serve signaling functions in the vasculature, and hypoxia has been associated with increased reactive oxygen species production. NADPH oxidase 4 (Nox4) is a reactive oxygen species-producing enzyme that is highly expressed in the endothelium, yet its specific role is unknown. We sought to determine the role of Nox4 in the endothelial response to hypoxia.

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