Absence of SOCS3 in the Cardiomyocyte Increases Mortality in a gp130-Dependent Manner Accompanied by Contractile Dysfunction and Ventricular Arrhythmias | Zendy

Toshitaka Yajima | Zendy; Yoshiteru Murofushi | Zendy; Hanbing Zhou | Zendy; Stanley Park | Zendy; Jonathan Housman | Zendy; Zhaohua Zhong | Zendy; Michinari Nakamura | Zendy; Mitsuyo Machida | Zendy; KyungKuk Hwang | Zendy; Yusu Gu | Zendy; Nancy D. Dalton | Zendy; Tomoko Yajima | Zendy; Hideo Yasukawa | Zendy; Kirk L. Peterson | Zendy; Kirk U. Knowlton | Zendy

Open Access

Absence of SOCS3 in the Cardiomyocyte Increases Mortality in a gp130-Dependent Manner Accompanied by Contractile Dysfunction and Ventricular Arrhythmias

Author(s) -

Toshitaka Yajima,

Yoshiteru Murofushi,

Hanbing Zhou,

Stanley Park,

Jonathan Housman,

Zhaohua Zhong,

Michinari Nakamura,

Mitsuyo Machida,

KyungKuk Hwang,

Yusu Gu,

Nancy D. Dalton,

Tomoko Yajima,

Hideo Yasukawa,

Kirk L. Peterson,

Kirk U. Knowlton

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.028498

Subject(s) - medicine , cardiology , socs3 , glycoprotein 130 , endocrinology , cytokine , interleukin 6 , cancer , suppressor

Suppressor of cytokine signaling-3 (SOCS3) is a key negative-feedback regulator of the gp130 receptor that provides crucial signaling for cardiac hypertrophy and survival; however, an in vivo role of SOCS3 regulation on cardiac gp130 signaling remains obscure.

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