Determinants and Consequences of Renal Function Variations With Aldosterone Blocker Therapy in Heart Failure Patients After Myocardial Infarction | Zendy

Patrick Rossignol | Zendy; John G.F. Cleland | Zendy; Sunil Bhandari | Zendy; Stéphane Tala | Zendy; Finn Gustafsson | Zendy; Renaud Fay | Zendy; Zohra Lamiral | Zendy; Daniela Dobre | Zendy; Bertram Pitt | Zendy; Faı̈ez Zannad | Zendy

Open Access

Determinants and Consequences of Renal Function Variations With Aldosterone Blocker Therapy in Heart Failure Patients After Myocardial Infarction

Author(s) -

Patrick Rossignol,

John G.F. Cleland,

Sunil Bhandari,

Stéphane Tala,

Finn Gustafsson,

Renaud Fay,

Zohra Lamiral,

Daniela Dobre,

Bertram Pitt,

Faı̈ez Zannad

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.028282

Subject(s) - medicine , eplerenone , heart failure , cardiology , myocardial infarction , ejection fraction , renal function , mineralocorticoid receptor , aldosterone , placebo , odds ratio , spironolactone , alternative medicine , pathology

We evaluated the effect of the selective mineralocorticoid receptor antagonist eplerenone on renal function and the interaction between changes in renal function and subsequent cardiovascular outcomes in patients with heart failure and left ventricular systolic dysfunction after an acute myocardial infarction in the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS).

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