Insulin Receptor Substrate 1 Gene Variation Modifies Insulin Resistance Response to Weight-Loss Diets in a 2-Year Randomized Trial | Zendy

Qibin Qi | Zendy; George A. Bray | Zendy; Steven R. Smith | Zendy; Frank B. Hu | Zendy; Frank M. Sacks | Zendy; Lu Qi | Zendy

Open Access

Insulin Receptor Substrate 1 Gene Variation Modifies Insulin Resistance Response to Weight-Loss Diets in a 2-Year Randomized Trial

Author(s) -

Qibin Qi,

George A. Bray,

Steven R. Smith,

Frank B. Hu,

Frank M. Sacks,

Lu Qi

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.025767

Subject(s) - medicine , insulin resistance , endocrinology , weight loss , insulin receptor , insulin , randomized controlled trial , irs1 , insulin sensitivity , type 2 diabetes , insulin response , obesity , diabetes mellitus , plasma glucose

Common genetic variants in the insulin receptor substrate 1 (IRS1) gene have been recently associated with insulin resistance and hyperinsulinemia. We examined whether the best-associated variant modifies the long-term changes in insulin resistance and body weight in response to weight-loss diets in Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial.

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