m-Calpain Induction in Vascular Endothelial Cells on Human and Mouse Atheromas and Its Roles in VE-Cadherin Disorganization and Atherosclerosis | Zendy

Takuro Miyazaki | Zendy; Yoshitaka Taketomi | Zendy; Masafumi Takimoto | Zendy; XiaoFeng Lei | Zendy; Shigeko Arita | Zendy; Joori KimKaneyama | Zendy; Satoru Arata | Zendy; Hisayuki Ohata | Zendy; Hidekazu Ota | Zendy; Makoto Murakami | Zendy; Akira Miyazaki | Zendy

Open Access

m-Calpain Induction in Vascular Endothelial Cells on Human and Mouse Atheromas and Its Roles in VE-Cadherin Disorganization and Atherosclerosis

Author(s) -

Takuro Miyazaki,

Yoshitaka Taketomi,

Masafumi Takimoto,

XiaoFeng Lei,

Shigeko Arita,

Joori KimKaneyama,

Satoru Arata,

Hisayuki Ohata,

Hidekazu Ota,

Makoto Murakami,

Akira Miyazaki

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.021675

Subject(s) - calpain , lysophosphatidylcholine , ldl receptor , medicine , apolipoprotein b , cadherin , microbiology and biotechnology , lipoprotein , proinflammatory cytokine , apolipoprotein e , inflammation , biology , biochemistry , cholesterol , cell , enzyme , phospholipid , disease , membrane , phosphatidylcholine

Although dysfunction of VE-cadherin-mediated adherence junctions in vascular endothelial cells (ECs) is thought to be one of the initial steps of atherosclerosis, little is known regarding how VE-cadherin is disrupted during atherogenic development. This study focused on the role of calpain, an intracellular cysteine protease, in the proteolytic disorganization of VE-cadherin and subsequent progression of atherosclerosis.

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