Controlled and Cardiac-Restricted Overexpression of the Arginine Vasopressin V1A Receptor Causes Reversible Left Ventricular Dysfunction Through Gα q -Mediated Cell Signaling | Zendy

Xue Li | Zendy; Tung O. Chan | Zendy; Valerie D. Myers | Zendy; Ibrul Chowdhury | Zendy; Xue-Qian Zhang | Zendy; Jianliang Song | Zendy; Jin Zhang | Zendy; Jocelyn Andrel | Zendy; Hajime Funakoshi | Zendy; Jeffrey Robbins | Zendy; Walter J. Koch | Zendy; Terry Hyslop | Zendy; Joseph Y. Cheung | Zendy; Arthur M. Feldman | Zendy

Open Access

Controlled and Cardiac-Restricted Overexpression of the Arginine Vasopressin V1A Receptor Causes Reversible Left Ventricular Dysfunction Through Gα _q -Mediated Cell Signaling

Author(s) -

Xue Li,

Tung O. Chan,

Valerie D. Myers,

Ibrul Chowdhury,

Xue-Qian Zhang,

Jianliang Song,

Jin Zhang,

Jocelyn Andrel,

Hajime Funakoshi,

Jeffrey Robbins,

Walter J. Koch,

Terry Hyslop,

Joseph Y. Cheung,

Arthur M. Feldman

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.021352

Subject(s) - endocrinology , medicine , vasopressin , arginine vasopressin receptor 2 , heart failure , receptor , transgene , cardiac function curve , biology , antagonist , biochemistry , gene

[Arg8]-vasopressin (AVP) activates 3 G-protein-coupled receptors: V1A, V2, and V1B. The AVP-V1A receptor is the primary AVP receptor in the heart; however, its role in cardiac homeostasis is controversial. To better understand AVP-mediated signaling in the heart, we created a transgenic mouse with controlled overexpression of the V1A receptor.

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