Acute Hypoglycemia Decreases Myocardial Blood Flow Reserve in Patients With Type 1 Diabetes Mellitus and in Healthy Humans | Zendy

Omer Rana | Zendy; Christopher D. Byrne | Zendy; David Kerr | Zendy; David Coppini | Zendy; Soha Zouwail | Zendy; Roxy Senior | Zendy; Joe Begley | Zendy; Jeremy Walker | Zendy; Kim Greaves | Zendy

Open Access

Acute Hypoglycemia Decreases Myocardial Blood Flow Reserve in Patients With Type 1 Diabetes Mellitus and in Healthy Humans

Author(s) -

Omer Rana,

Christopher D. Byrne,

David Kerr,

David Coppini,

Soha Zouwail,

Roxy Senior,

Joe Begley,

Jeremy Walker,

Kim Greaves

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.992297

Subject(s) - medicine , hypoglycemia , hyperinsulinemic hypoglycemia , endocrinology , cardiology , diabetes mellitus , confidence interval , type 2 diabetes mellitus , glucose clamp technique , hyperinsulinism , insulin , insulin resistance , pancreatic hormone

Hypoglycemia is associated with increased cardiovascular mortality, but the reason for this association is poorly understood. We tested the hypothesis that the myocardial blood flow reserve (MBFR) is decreased during hypoglycemia using myocardial contrast echocardiography in patients with type 1 diabetes mellitus (DM) and in healthy control subjects.

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