Remote Ischemic Preconditioning Protects the Brain Against Injury After Hypothermic Circulatory Arrest | Zendy

Hanna Jensen | Zendy; Stavros Loukogeorgakis | Zendy; Fredrik Yannopoulos | Zendy; Eija Rimpiläinen | Zendy; Axel Petzold | Zendy; Hannu Tuominen | Zendy; Pasi Lepola | Zendy; Raymond J. MacAllister | Zendy; John Deanfield | Zendy; Tuomas Mäkelä | Zendy; Kirsi Alestalo | Zendy; Kai Kiviluoma | Zendy; Vesa Anttila | Zendy; Victor Tsang | Zendy; Tatu Juvonen | Zendy

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Remote Ischemic Preconditioning Protects the Brain Against Injury After Hypothermic Circulatory Arrest

Author(s) -

Hanna Jensen,

Stavros Loukogeorgakis,

Fredrik Yannopoulos,

Eija Rimpiläinen,

Axel Petzold,

Hannu Tuominen,

Pasi Lepola,

Raymond J. MacAllister,

John Deanfield,

Tuomas Mäkelä,

Kirsi Alestalo,

Kai Kiviluoma,

Vesa Anttila,

Victor Tsang,

Tatu Juvonen

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.986497

Subject(s) - medicine , ischemic preconditioning , anesthesia , ischemia , interquartile range , cardiopulmonary bypass , hypothermia , neuroprotection , brain ischemia , analysis of variance , cardiology

Ischemic preconditioning (IPC) is a mechanism protecting tissues from injury during ischemia and reperfusion. Remote IPC (RIPC) can be elicited by applying brief periods of ischemia to tissues with ischemic tolerance, thus protecting vital organs more susceptible to ischemic damage. Using a porcine model, we determined whether RIPC of the limb is protective against brain injury caused by hypothermic circulatory arrest (HCA).

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