Deletion of Cardiomyocyte Mineralocorticoid Receptor Ameliorates Adverse Remodeling After Myocardial Infarction | Zendy

Daniela Fraccarollo | Zendy; Stefan Berger | Zendy; Paolo Galuppo | Zendy; Susanne Kneitz | Zendy; Lutz Hein | Zendy; Günther Schütz | Zendy; Stefan Frantz | Zendy; Georg Ertl | Zendy; Johann Bauersachs | Zendy

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Deletion of Cardiomyocyte Mineralocorticoid Receptor Ameliorates Adverse Remodeling After Myocardial Infarction

Author(s) -

Daniela Fraccarollo,

Stefan Berger,

Paolo Galuppo,

Susanne Kneitz,

Lutz Hein,

Günther Schütz,

Stefan Frantz,

Georg Ertl,

Johann Bauersachs

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.983023

Subject(s) - medicine , mineralocorticoid receptor , myocardial infarction , mineralocorticoid , cardiology , ventricular remodeling , receptor , endocrinology

Mineralocorticoid receptor (MR) blockade improves morbidity and mortality among patients with heart failure; however, the underlying mechanisms are still under investigation. We studied left ventricular remodeling after myocardial infarction in mice with cardiomyocyte-specific inactivation of the MR gene (MR(MLCCre)) that were generated with a conditional MR allele (MR(flox)) in combination with a transgene expressing Cre recombinase under control of the myosin light-chain (MLC2a) gene promoter.

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