Open AccessRepolarization Alternans Reveals Vulnerability to Human Atrial Fibrillation
Author(s) -
Sanjiv M. Narayan,
Michael R. Franz,
Paul Clopton,
Étienne Pruvot,
David E. Krummen
Publication year - 2011
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.110.977827
Subject(s) - medicine , atrial fibrillation , cardiology , repolarization , fibrillation , electrophysiology
The substrates for human atrial fibrillation (AF) are poorly understood, but involve abnormal repolarization (action potential duration [APD]). We hypothesized that beat-to-beat oscillations in APD may explain AF substrates, and why vulnerability to AF forms a spectrum from control subjects without AF to patients with paroxysmal then persistent AF.
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