Blocking of Frizzled Signaling With a Homologous Peptide Fragment of Wnt3a/Wnt5a Reduces Infarct Expansion and Prevents the Development of Heart Failure After Myocardial Infarction | Zendy

Hilde Laeremans | Zendy; Tilman M. Hackeng | Zendy; Marc A. M. J. van Zandvoort | Zendy; Victor L. Thijssen | Zendy; Ben Janssen | Zendy; H. C. J. OTTENHEIJM | Zendy; Jos F.M. Smits | Zendy; W. Matthijs Blankesteijn | Zendy

Open Access

Blocking of Frizzled Signaling With a Homologous Peptide Fragment of Wnt3a/Wnt5a Reduces Infarct Expansion and Prevents the Development of Heart Failure After Myocardial Infarction

Author(s) -

Hilde Laeremans,

Tilman M. Hackeng,

Marc A. M. J. van Zandvoort,

Victor L. Thijssen,

Ben Janssen,

H. C. J. OTTENHEIJM,

Jos F.M. Smits,

W. Matthijs Blankesteijn

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.976969

Subject(s) - frizzled , wnt signaling pathway , wnt3a , medicine , heart failure , microbiology and biotechnology , lrp5 , lrp6 , myocardial infarction , pharmacology , receptor , signal transduction , cancer research , biology

The molecular pathways that control the wound healing after myocardial infarction (MI) are not completely elucidated. One of these pathways is the Wnt/Frizzled pathway. In this study, we evaluated Frizzled as a novel therapeutic target for MI. These Frizzled proteins act as receptors for Wnt proteins and were previously shown to be expressed in the healing infarct.

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