Effects of HIV Protease Inhibitors on Progression of Monocrotaline- and Hypoxia-Induced Pulmonary Hypertension in Rats | Zendy

Guillaume GaryBobo | Zendy; Amal Houssaïni | Zendy; Valérie Amsellem | Zendy; Dominique Rideau | Zendy; Pierre Pacaud | Zendy; Aline Perrin | Zendy; Jérémy Brégeon | Zendy; Élisabeth Marcos | Zendy; JeanLuc DuboisRandé | Zendy; Olivier Sitbon | Zendy; Laurent Savale | Zendy; Serge Adnot | Zendy

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Effects of HIV Protease Inhibitors on Progression of Monocrotaline- and Hypoxia-Induced Pulmonary Hypertension in Rats

Author(s) -

Guillaume GaryBobo,

Amal Houssaïni,

Valérie Amsellem,

Dominique Rideau,

Pierre Pacaud,

Aline Perrin,

Jérémy Brégeon,

Élisabeth Marcos,

JeanLuc DuboisRandé,

Olivier Sitbon,

Laurent Savale,

Serge Adnot

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.973750

Subject(s) - amprenavir , medicine , protein kinase b , pulmonary hypertension , hypoxia (environmental) , pulmonary artery , right ventricular hypertrophy , nitric oxide synthase , pharmacology , gsk 3 , endocrinology , phosphorylation , nitric oxide , biology , biochemistry , protease , chemistry , enzyme , organic chemistry , hiv 1 protease , oxygen

Pulmonary hypertension (PH) is among the complications of HIV infection. Combination antiretroviral therapy may influence the progression of HIV-related PH. Because Akt signaling is a potential molecular target of HIV protease inhibitors (HPIs), we hypothesized that these drugs altered monocrotaline- and hypoxia-induced PH in rats by downregulating the Akt pathway, thereby inhibiting pulmonary artery smooth muscle cell proliferation.

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