Upregulation of the 5-Lipoxygenase Pathway in Human Aortic Valves Correlates With Severity of Stenosis and Leads to Leukotriene-Induced Effects on Valvular Myofibroblasts | Zendy

Edit Nagy | Zendy; Daniel Andersson | Zendy; Kenneth Caidahl | Zendy; Maria J. Eriksson | Zendy; Per Eriksson | Zendy; Anders FrancoCereceda | Zendy; Göran K. Hansson | Zendy; Magnus Bäck | Zendy

Open Access

Upregulation of the 5-Lipoxygenase Pathway in Human Aortic Valves Correlates With Severity of Stenosis and Leads to Leukotriene-Induced Effects on Valvular Myofibroblasts

Author(s) -

Edit Nagy,

Daniel Andersson,

Kenneth Caidahl,

Maria J. Eriksson,

Per Eriksson,

Anders FrancoCereceda,

Göran K. Hansson,

Magnus Bäck

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.966846

Subject(s) - medicine , calcification , proinflammatory cytokine , downregulation and upregulation , leukotriene b4 , inflammation , stenosis , myofibroblast , pathology , endocrinology , biology , fibrosis , biochemistry , gene

The development of aortic valve stenosis is not only associated with calcification and extracellular matrix remodeling, but also with inflammation. The aim of this study was to determine the role of proinflammatory signaling through the leukotriene (LT) pathway in aortic stenosis.

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