Growth Factor Therapy and Autologous Lymph Node Transfer in Lymphedema
Author(s) -
Markku Lähteenvuo,
Krista Honkonen,
Tomi V. Tervala,
Tuomas Tammela,
Erkki Suominen,
Johanna Lähteenvuo,
Ivana Kholová,
Kari Alitalo,
Seppo YläHerttuala,
Anne Saaristo
Publication year - 2011
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.110.965384
Subject(s) - medicine , lymphatic system , lymphedema , lymphangiogenesis , lymph node , vascular endothelial growth factor , lymph , vascular endothelial growth factor c , lymphatic vessel , edema , pathology , surgery , vascular endothelial growth factor a , vegf receptors , cancer , breast cancer , metastasis
Lymphedema after surgery, infection, or radiation therapy is a common and often incurable problem. Application of lymphangiogenic growth factors has been shown to induce lymphangiogenesis and to reduce tissue edema. The therapeutic effect of autologous lymph node transfer combined with adenoviral growth factor expression was evaluated in a newly established porcine model of limb lymphedema.
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