Signal Transducers and Activators of Transcription-3/Pim1 Axis Plays a Critical Role in the Pathogenesis of Human Pulmonary Arterial Hypertension | Zendy

Roxane Paulin | Zendy; Audrey Courboulin | Zendy; Jolyane Meloche | Zendy; Vincent Mainguy | Zendy; Eric Dumas de la Roque | Zendy; Nehmé Saksouk | Zendy; Jacques Côté | Zendy; Steeve Provencher | Zendy; Mark A. Sussman | Zendy; Sébastien Bonnet | Zendy

Open Access

Signal Transducers and Activators of Transcription-3/Pim1 Axis Plays a Critical Role in the Pathogenesis of Human Pulmonary Arterial Hypertension

Author(s) -

Roxane Paulin,

Audrey Courboulin,

Jolyane Meloche,

Vincent Mainguy,

Eric Dumas de la Roque,

Nehmé Saksouk,

Jacques Côté,

Steeve Provencher,

Mark A. Sussman,

Sébastien Bonnet

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.963314

Subject(s) - pim1 , medicine , stat3 , stat protein , cancer research , pulmonary hypertension , pulmonary artery , signal transduction , transcription factor , apoptosis , kinase , cell growth , microbiology and biotechnology , pharmacology , biology , phosphorylation , biochemistry , gene , serine

Pulmonary artery hypertension (PAH) is a proliferative disorder associated with enhanced pulmonary artery smooth muscle cell proliferation and suppressed apoptosis. The sustainability of this phenotype required the activation of a prosurvival transcription factor like signal transducers and activators of transcription-3 (STAT3) and nuclear factor of activated T cell (NFAT). Because these factors are implicated in several physiological processes, their inhibition in PAH patients could be associated with detrimental effects. Therefore, a better understanding of the mechanism accounting for their expression/activation in PAH pulmonary artery smooth muscle cells is of great therapeutic interest.

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