Paradigm of Genetic Mosaicism and Lone Atrial Fibrillation | Zendy

Isabelle Thibodeau | Zendy; Ji Xu | Zendy; Qiuju Li | Zendy; Gele Liu | Zendy; Khanh Lam | Zendy; John P. Veinot | Zendy; David Birnie | Zendy; Douglas L. Jones | Zendy; Andrew D. Krahn | Zendy; Robert Lemery | Zendy; Bruce J. Nicholson | Zendy; Michael H. Gollob | Zendy

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Paradigm of Genetic Mosaicism and Lone Atrial Fibrillation

Author(s) -

Isabelle Thibodeau,

Ji Xu,

Qiuju Li,

Gele Liu,

Khanh Lam,

John P. Veinot,

David Birnie,

Douglas L. Jones,

Andrew D. Krahn,

Robert Lemery,

Bruce J. Nicholson,

Michael H. Gollob

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.961227

Subject(s) - frameshift mutation , genetics , mutation , connexin , medicine , biology , gene , gap junction , intracellular

Atrial fibrillation (AF) is the most common sustained arrhythmia observed in otherwise healthy individuals. Most lone AF cases are nonfamilial, leading to the assumption that a primary genetic origin is unlikely. In this study, we provide data supporting a novel paradigm that atrial tissue-specific genetic defects may be associated with sporadic cases of lone AF.

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