Open AccessSilent Information Regulator 1 Protects the Heart From Ischemia/Reperfusion
Author(s) -
ChiaoPo Hsu,
Peiyong Zhai,
Takanobu Yamamoto,
Yasuhiro Maejima,
Shouji Matsushima,
Nirmala Hariharan,
Dan Shao,
Hiromitsu Takagi,
Shinichi Oka,
Junichi Sadoshima
Publication year - 2010
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.110.958033
Subject(s) - medicine , regulator , ischemia , cardiology , reperfusion injury , biochemistry , gene , chemistry
Silent information regulator 1 (Sirt1), a class III histone deacetylase, retards aging and protects the heart from oxidative stress. We here examined whether Sirt1 is protective against myocardial ischemia/reperfusion (I/R).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom